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ARPN Journal of Engineering and Applied Sciences

In silico analysis of small molecules from Spirulina platensis as a loop dierutic and anti-inflammatory agent

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Author S. Putut H. Riyadi, Eko Susanto, Apri D. Anggo and Muhammad H. Arifin
e-ISSN 1819-6608
On Pages 1554-1566
Volume No. 18
Issue No. 13
Issue Date September 13, 2023
Keywords Spirulina platensis, loop diuretic, anti-inflammatory, in silico.


Spirulina platensis has been used as food for centuries by different populations and has only been rediscovered in recent years. Once classified as the - blue-green algae’’, it does not strictly speaking belong to the algae, even though for convenience it continues to be referred to in that way. The current study aimed to explore the potential of Spirulina platensis extract as a loop diuretic and anti-inflammatory agent in silico. Gas Chromatography-Mass Spectrometry was used to identify the bioactive compounds in the Spirulina platensis extract. Seventeen bioactive compounds found from Spirulina platensis were then analyzed the loop diuretic-related activity using the Prediction of Activity Spectra for Substances (PASS) server. Furthermore, the SwissADME web server and ProTox II were used to evaluate drug-likeness, excretion, metabolism, distribution, absorption, and toxicity of the small molecule from Spirulina platensis based on PASS online prediction. There were 13 compounds found in Spirulina platensis that are related to loop diuretic and anti-inflammatory properties. Furthermore, several small molecules of Spirulina platensis (SP) have good bioavailability based on Swiss ADME analysis. Most of the Spirulina platensis small molecules followed the Lipinski rules and had high gastrointestinal (GI) absorption values. Based on these findings, small molecules of Spirulina platensis have the potential to act as loop diuretic and anti-inflammatory agents.


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